If you plan to stay or take a vacation in Manhattan, you will find luxury hotels that are very comfortable and luxurious apartments where you can build yourself, and use this city as a launching point for sightseeing trips to the countryside, cities and surrounding cities are beautiful around it.
Stopping at San Isidro will give you the opportunity to shop. The train then takes you to Tigre in the heart of the Delta. Here are various boat trips on the river and channels, ferries to the islands, Isla Martin Garcia, old prison camps, and fortresses and water sports, and fishing. You can check out https://livehollingsworth.com to book the best apartment for your next stay.
There are restaurants and hotels where you can have lunch, and a guided tour to take you around. You can also roam alone in absorbing the atmosphere. Remember that it's in a different country, so don't forget your passport.
If you are interested in a nice change from city lights, try a weekend at Estancia. Within easy reach, you should be able to find estancias that bring guests and give them a taste of traditional estancia life. Estancia is an Argentinian equivalent of cattle farming. The gauchos are 'cowboys' and cattle and horses are part of their life and culture.
Some of these estancias come from one or even two centuries, and they often take the form of French, Spanish or American colonial-style houses that have been beautifully restored and converted to pay guests. They are still continuing their livestock business and guests are invited to take part. If you enjoy riding, you will find yourself at home here.